Aminopeptidase N in arterial hypertension
نویسندگان
چکیده
منابع مشابه
Dietary NaCl regulates renal aminopeptidase N: relevance to hypertension in the Dahl rat.
Aminopeptidase N (APN) is an abundant metallohydrolase in the brush border of kidney proximal tubule cells that degrades angiotensin III (Ang III) to angiotensin IV (Ang IV) and, along with dipeptidylaminopeptidase, degrades Ang IV. We examined the impact of a high-salt diet on renal APN activity and transcript abundance in the Sprague-Dawley and Dahl salt-sensitive (SS/Jr) rat strains. APN tra...
متن کاملEveryday General Practitioner Challenges: Treatment of Arterial Hypertension (2)
This article has no abstract
متن کاملImpaired angiogenesis in aminopeptidase N-null mice.
Aminopeptidase N (APN, CD13; EC 3.4.11.2) is a transmembrane metalloprotease with several functions, depending on the cell type and tissue environment. In tumor vasculature, APN is overexpressed in the endothelium and promotes angiogenesis. However, there have been no reports of in vivo inactivation of the APN gene to validate these findings. Here we evaluated, by targeted disruption of the APN...
متن کاملThe Importance of Electrocardiography in Pediatric Patients with Pulmonary Arterial Hypertension in Follow- up
Background: Right Ventricular (RV) hypertrophy is an adaptive response to chronic RV pressure overload in patients with pulmonary hypertension. We investigated the relationships between RV hypertrophy indicators, including electrocardiography, the percentage oxygen saturation (SaO2%), body mass index (BMI), and blood uric acid levels in patients with...
متن کاملArterial Hypertension in Dogs
Various methods were devised in attempts to produce chronic hypertension in dogs. The induction of anxiety was unsuccessful. Bilateral renal denervation combined with injections of epinephrine appeared to produce temporary hypertension. Permanent hypertension was induced by unilateral renal ischemia with the other kidney left intact only in dogs of nervous temperament. Certain dogs were extreme...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Heart Failure Reviews
سال: 2007
ISSN: 1382-4147,1573-7322
DOI: 10.1007/s10741-007-9061-y